Journal article
Progressive impairments in executive function in the APP/PS1 model of Alzheimer's disease as measured by translatable touchscreen testing
A Shepherd, JKH Lim, VHY Wong, AM Zeleznikow-Johnston, L Churilov, CTO Nguyen, BV Bui, AJ Hannan, EL Burrows
Neurobiology of Aging | Published : 2021
Abstract
Executive function deficits in Alzheimer's disease (AD) occur early in disease progression and may be predictive of cognitive decline. However, no preclinical studies have identified deficits in rewarded executive function in the commonly used APPSwe/PS1∆E9 (APP/PS1) mouse model. To address this, we assessed 12-26 month old APP/PS1 mice on rewarded reversal and/or extinction tasks. 16-month-old, but not 13- or 26-month-old, APP/PS1 mice showed an attenuated rate of extinction. Reversal deficits were seen in 22-month-old, but not 13-month-old APP/PS1 animals. We then confirmed that impairments in reversal were unrelated to previously reported visual impairments in both AD mouse models and hum..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We would like to thank past and present laboratory members for useful discussions and technical assistance. We thank Britany Cuic, Maddison Ible, Daniel Drieberg, Shannon Currin Craig Thomp-son and Brett Purcell for their assistance in mouse husbandry and management of equipment. Thank you to Nippy's Ltd, for the do-nation of Ice Strawberry milk to our study. A.S is supported by an Australian Government Research Training Program Scholarship and Yulgilbar top-up scholarship. A.M.Z.J is supported by an Aus-tralian Government Research Training Program Scholarship A.J.H. is a National Health and Medical Research Council (NHMRC) Princi-pal Research Fellow and has been supported by an Australian Re-search Council (ARC) FT3 Future Fellowship (FT100100835) . E.L.B. is supported by a NHMRC-ARC Dementia Research Development Fellowship. C.T.O.N is supported by an Australian Research Council (ARC) Linkage grant (LP160100126) and a Melbourne Research Fel-lowship. J.K.H.L. is supported by the Guelma-Alaexander fellowship in Neuroscience and V.H.Y.W. are supported by an Australian Re-search Council (ARC) Linkage grant (LP160100126) . This work was supported by directed research costs associated to a NHMRC-ARC Dementia Research Development fellowship. We would also like to acknowledge the operational infrastructure support from the State Government of Victoria.